N-acetyl-l-cysteine ethyl ester (NACET) induces the transcription factor NRF2 and prevents retinal aging and diabetic retinopathy

• N-acetylcysteine ethyl ester (NACET) boosts cysteine, glutathione and activates NRF2 in RPE cells. • Cysteinylation of KEAP1 Cys226/Cys613 drives NRF2 activation by NACET. • Oral NACET activates NRF2 signaling in the retina in vivo. • NACET reduces retinal aging markers and diabetic neurodegenerat…

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