The microglia-derived protein sema4ab attenuates regenerative neurogenesis after spinal cord injury in zebrafish (opens in new tab)

Zebrafish can regenerate neurons after spinal cord injury, but the mechanisms influencing this ability remain unknown. This study shows that sema4ab, a protein expressed in lesion-reactive microglia, attenuates regenerative neurogenesis by directly regulating neural progenitors and altering cytokine signaling in the niche.