Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation (opens in new tab)

Author summary Oligodendrocytes are glial cells in the central nervous system that form myelin, the insulating sheath enabling rapid nerve signal transmission. Myelination is a dynamic process influenced by neuronal activity, with calcium (Ca2+) signaling emerging as a key regulator. These signals include spontaneous local Ca2+ transients (SCaLTs), generated intrinsically or facilitated by membrane voltage, as well as evoked responses triggered by neurotransmitters like ATP and glutamate. To ...