AI-driven discovery of GPNMB CAR T cells as a multi-cancer therapy (opens in new tab)

An AI-guided framework integrating high-resolution cellular atlases, public knowledge databases, and large language models enables a modular framework for CAR T cell target discovery. GPNMB emerged as a versatile candidate antigen, enabling the development of GPNMB CAR T cells with potent activity in multiple xenograft mouse models of cancer.