Loss of PINK1 causes age-dependent mitochondrial trafficking deficits in nigrostriatal dopaminergic neurons via aberrant p38 MAPK activation

Mutations in PTEN-induced putative kinase 1 (PINK1) cause early-onset, autosomal-recessive Parkinson’s disease (PD). While previous studies have shown age-related declines in dopamine release and ATP levels in Pink1−/− mice, the mechanisms remain unclear. Using a novel TH-Mito-Dendra2 transgenic mou…

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