Drug peptides defy shape rules, activating receptors without full spiral form (opens in new tab)

When many of us think about how drugs work in the body, we may first think about how a drug gets into the body, such as a pill versus an injection. In the Gellman Group at the UW–Madison Department of Chemistry, researchers are instead thinking about how a drug behaves after it reaches its target, which is critical for effective drug performance. The cells in our bodies must receive and respond to information from their environment for healthy function, and when information flow is disrupted,...