Aging is a privilege we should all enthusiastically embrace; but with all the longevity supplements, biohacking methods, anti-aging strategies, and injectable treatments swirling around, it’s easy to lose the plot. When it comes to longevity, how we care for ourselves now is the biggest indicator of how we’ll age. “Clinically, healthy aging means keeping people active, mentally sharp, and able to fully participate in their lives for as long as possible,” explains physician and founder of Parsley Health Robin Berzin, MD. “Living longer without strength, mobility, or cognitive clarity isn’t a win.” The distinction between lifespan versus health span is an important one. “The goal with longevity isn’t just *m…
Aging is a privilege we should all enthusiastically embrace; but with all the longevity supplements, biohacking methods, anti-aging strategies, and injectable treatments swirling around, it’s easy to lose the plot. When it comes to longevity, how we care for ourselves now is the biggest indicator of how we’ll age. “Clinically, healthy aging means keeping people active, mentally sharp, and able to fully participate in their lives for as long as possible,” explains physician and founder of Parsley Health Robin Berzin, MD. “Living longer without strength, mobility, or cognitive clarity isn’t a win.” The distinction between lifespan versus health span is an important one. “The goal with longevity isn’t just more time; it’s more quality time,” adds Dr. Berzin. Anti-aging supplements, then, focus not on looking better, but supporting you feeling better.
Vogue’s Favorite Longevity Supplements:
Best NAD+:
Tru Niagen Pro NAD+
Best Resveratrol:
Thorne ResveraCel
Best Omega-3
Orlo Omega 3 Algae Oil 1000mg
Genetics play a role, of course, but not as much as you think. “Genetics are the dictionary, but behavior writes our story,” says board-certified physician and founder of LifeSpan Medicine Chris Renna, DO. “Behavior influences the epigenetic changes that play the biggest role in who we are and what we are able to do.” There are a few evidence-backed pillars of longevity science. “Physical activity (especially resistance training), sleep quality, nutrition, and stress regulation remain the strongest levers we have to healthy aging, according to scientific research,” explains doctor and clinical advisor in aging research at King’s College University Michael Sagner, MD. “Most underestimate the power of the basics, including caring for your mental health and leading a fulfilling social life, and immediately jump to injections, infusions, and unproven ‘fancy’ interventions.”
However, modern life, stress, and nutrition means we all may need a little extra help from time to time and the best longevity supplements can act as a support system to help fill in any nutritional gaps. If you want to embrace aging with open arms, but look and feel as good as humanly possible while doing it, we’ve tapped three doctors and longevity experts to dish on the best longevity supplements and strategies to support longer, healthier years.
In This Story:
- Do anti-aging supplements actually work?
- Which supplements are best for anti-aging?
- Are Supplements the Best Way to Support Healthy Aging?
- How We Tested
- Meet the Experts
Best NAD+ Supplement For Longevity: Tru Niagen Pro
Tru Niagen
Pro NAD+
- Why We Love It: A favorite of many longevity experts, including Dr. Sagner, nicotinamide adenine dinucleotide (aka NAD+) supports virtually every major cellular function in your body. “While there is no one magic bullet to replace foundational behaviors like sleep and nutrition, elevating NAD⁺ with NR supplementation addresses aging at the cellular level and can meaningfully support healthy aging and overall vitality,” says Dr. Sagner. This capsule contains a patented ingredient called Niagen—which includes nicotinamide riboside (NR), a unique form of vitamin B3 and precursor to NAD+ that’s clinically studied for its safety and efficacy in over 35 peer-reviewed published research papers. “Clinical research demonstrates the potential benefits of NAD+ support with Niagen on key health areas, including heart, brain, muscle, inflammation, immune health, cellular energy production and repair, and lifestyle stress management,” adds Dr. Sagner, who also is an advisor for Niagen Bioscience. Niagen, who also partners with highly regarded institutions like Mayo Clinic and Harvard, takes third-party testing seriously: 90% of their studies are independently-researched which means they’re conducted or funded by a third-party—so you can rest assured what’s in the bottle is stringently tested and safe.
- Key Ingredients: Niagen®
- Form: Capsule
- Dose: 2 capsules once a day
- More to know: NSF-certified, third-party tested, vegetarian, gluten-free, allergen-free
Best Skin Supplement For Longevity: Ritual HyaCera Daily Skin Hydration Supplement
Ritual
HyaCera Daily Skin Hydration Supplement
- Why We Love It: As we age, we naturally produce less hyaluronic acid—a key molecule with incredible moisturizing properties that’s important to keep skin hydrated, plump, and supple, support wound healing, cushion joints, and encourage tissue repair and regeneration. While we most often know about it as a topical—in serums or creams—you can also supplement with it orally for major skin benefits. This vegan capsule is powered by two clinically-studied vitamin complexes—Ceratiq® and Hyabest®—the latter which harnesses a bio-fermented, lower molecular weight hyaluronic acid, for smooth, plump, glowing skin.
- Key Ingredients: Hyaluronic Acid, glycolipids, ceramides
- Form: Capsule
- Serving Size: 1 capsule
- More To Know: Non-GMO Project verified, Clean Label Project certified, ClimeCo certified
Best Resveratrol Supplement For Longevity: Thorne ResveraCel
Thorne
ResveraCel
- Why We Love It: Powerhouse antioxidant resveratrol is a master defender against free radicals associated with cellular aging throughout the body. It has also received recent buzz for its promising benefits that support healthy aging through multiple biological pathways—but it’s one small piece of the puzzle. This high-quality formula from Thorne pairs trans-resveratrol and quercetin phytosomes with NR, a precursor to NAD+ that can stimulate NAD+ production, to help support cellular energy and aging pathways. “It’s important to pick a science-backed NAD+ precursor if you decide to ‘boost’ your NAD+ levels,” says Dr. Sagner. “Nicotinamide riboside (NR) is a clinically studied NAD+ precursor that is the most effective because of its bioavailability.” Thorne also is rigorously tested and has worked with independent researchers at organizations such as Mayo Clinic and the National Institutes of Health to ensure its products are high performing, safe, and effective.
- Key Ingredients: Nicotinamide riboside hydrogen malate, quercetin phytosome, trans-resveratrol
- Form: Capsule
- Dose: 2 capsules
- More To Know: NSF-certified, GMP-verified, gluten-free, dairy-free, soy-free, third-party tested
Best Omega-3 Supplement For Longevity: Orlo Active Omega 3
Orlo
Omega 3 Algae Oil 1000mg
- Why We Love It: Even those who aren’t following a vegan or vegetarian diet will love this algae oil. It’s a fantastic plant-based source of the omega-3s EPA and DHA to help reach your daily goals—something essential for better health. According to this 2021 study, most Americans aren’t meeting the recommended intake of omega-3s. “The most compelling evidence exists where supplements support functional outcomes, such as omega-3s reducing cardiovascular events or creatine preserving muscle strength and independence,” says Dr. Berzin. “Health span extension appears to occur when supplements like omega-3s are integrated into broader interventions that reduce frailty, metabolic disease, and cognitive decline.” Orlo’s algae is grown in Iceland using geothermal energy and extracted through a process that doesn’t use any harmful chemicals so you can rest assured you’re getting an omega-3 supplement that’s free of toxins, mercury, and solvents.
- Key Ingredients: Algae oil
- Form: Soft gel capsule
- Dose: 2 capsules
- More To Know: NSF-certified, ISO certified, Vegan Society registered, third-party tested
Best Vitamin D Supplement For Longevity: Pure Encapsulations Vitamin D3
Pure Encapsulations
Vitamin D3
- Why We Love It: Known as the sunlight vitamin, vitamin D is one of those nutrients that is hard to get enough of. Because it plays a role in bone health, immune resilience, muscle health, balancing inflammation, and more, Dr. Sagner says vitamin D has strong clinical evidence to support longevity and healthy aging if you are deficient. And research shows that we may not be getting enough, even through a balanced diet. “In the US around 40% of the population can be deficient, especially during the darker months of the year when there is less sunlight,” he says. This formula offers an ideal dose—1000 IU—of vitamin D3 to maintain daily vitamin D levels without any common allergens, artificial flavors, filler ingredients, or GMOs in the formula.
- Key Ingredients: Vitamin D, cellulose
- Form: Capsule
- Dose: 1 capsule daily
- More To Know: Non-GMO, gluten-free, soy-free, dairy-free, wheat-free
Best Multivitamin Supplement For Longevity: Seed DM-02 Daily Multivitamin
Seed
DM-02 Daily Multivitamin
- Why We Love It: Seed continues to make some of our favorite supplements thanks to their clean, effective formulations and rigorous third-party testing for safety and efficacy. This daily multivitamin delivers comprehensive help by providing 100% of the daily value for over 20 top essential minerals and vitamins to help bring overall balance to your daily diet. “A quality multivitamin can cover individual deficiencies of B vitamins and minerals like magnesium which support DNA synthesis, clear cognition, and in the case of magnesium, act as a catalyst in hundreds of enzymatic reactions,” says Dr. Renna. By using bioactive or bioavailable forms of these trace minerals and vitamins, it’s a fantastic choice for daily anti-aging support.
- Key Ingredients: Vitamins A, B, C, D3, E, K1, zinc, selenium, copper, chromium
- Form: Capsule
- Dose: 1 capsule per day
- More to Know: Tested for heavy metals and free of glyphosate and AMPA, formulated to comply with Prop. 65, and without gluten, soy, dairy, and corn
Best Curcumin Supplement For Longevity: Designs For Health C3 Curcumin Complex
Designs For Health
C3 Curcumin Complex
- Why We Love It: The active ingredient in turmeric, curcumin, has been shown to help manage and reduce inflammation, making it ideal for those looking to support longevity. “Curcumin deserves mention as studies show improved vascular function and lower inflammatory markers, less joint pain, and improvements in certain cognitive abilities in middle‑aged/older adults,” says Dr. Renna. This capsule contains three curcuminoids (standardized to 95%) in an easy-to-take vegetarian capsule along with sunflower lecithin to enhance bioavailability and maximize absorption.
- Key Ingredients: Curcumin, bisdemethoxycurcumin, demethoxycurcumin
- Form: Capsule
- Dose: 1 capsule per day
- More To Know: Non-GMO, gluten-free, vegan, vegetarian
Best CoQ10 Supplement For Longevity: Integrative Therapeutics CoQ10
Integrative Therapeutics
CoQ10 100mg
- Why We Love It: Antioxidants are crucial soldiers against oxidative stress and free radical damage. CoQ10, a naturally occurring antioxidant compound found in our bodies necessary for the production of cellular energy, is one of the most powerful forms. “Mitochondria are the “batteries” that provide energy to your cells and the really interesting supplements are those that can help improve mitochondrial function,” says Dr. Renna. “Coenzyme Q10 (CoQ10), when given to older adults and cardiac patients, shows improved mitochondrial function, exercise capacity, reduced fatigue, and some reduction in cardiovascular events.” Only one capsule a day is all you need for 100mg of CoQ10, making it easy to incorporate into your daily routine.
- Key Ingredients: CoQ10
- Form: Capsule
- Dose: 1 capsule daily
Everything You Need To Know
Do anti-aging supplements actually work?
Anti-aging supplements should be just that—supplementary. While they can offer some benefits, they should be considered a small part that contributes in making your efforts toward an overall healthy lifestyle more effective. “Supplements can support, if not amplify, your efforts to meet your daily nutrient needs and help you achieve your longevity goals,” says Dr. Renna. “But they can’t replace a healthy diet, regular exercise, and adequate sleep.”
Which supplements are best for anti-aging?
Supplements can be powerful tools in achieving targeted effects when used appropriately. “While supplements don’t replace lifestyle choices, the right supplements can be highly beneficial,” says Dr. Berzin. “But it’s important to work with a provider who can personalize recommendations based on testing and clinical outcomes.” Below, a few longevity supplements with the greatest longevity benefits.
- NAD+: NAD+ is a critical coenzyme found in every cell that is essential for longevity. “It helps power two of the most fundamental jobs your cells do: make energy and repair themselves,” says Dr. Sagner. “It’s essential for converting food into ATP (cellular energy) and for activating enzymes involved in DNA repair, stress response, and metabolic balance–including sirtuins and PARPs, which are tightly linked to healthy aging processes.” NR is an efficient way to elevate NAD+ levels because it can penetrate the cell membrane directly. “Maintaining NAD+ levels supports the energy and repair systems that help keep cells resilient and functioning well over time,” says Dr. Sagner.
- Omega-3 Fatty Acids: Omega-3 fatty acids are linked to brain function, immune system, mood, focus, vision, inflammatory response, heart function, respiratory function, metabolic health, and more, making them key for healthier aging. However, we don’t naturally produce them so we have to get them in our diet or a quality supplement. “Omega 3 oils, as well as B vitamins, vitamin D, and certain mitochondrial support supplements have the most evidence in their favor to support longevity,” says Dr. Renna. “Omega 3 oils are important for brain health and reducing cardiovascular risk factors.”
- CoQ10: Coenzyme Q10 (CoQ10) is an antioxidant compound found naturally in every cell of our body that protects cells from free radicals which can damage our genetic material. “CoQ10 has been shown to improve egg quality for women and it’s important for mitochondrial function, especially in people taking statins,” says Dr. Berzin. Studies show it can potentially help prevent heart disease, some types of cancer. “Compounds like CoQ10 support mitochondrial function or act as antioxidants,” says Dr. Sagner. “But NAD+ precursors directly replenish a critical molecule required for energy metabolism and cellular repair, addressing one of the root drivers of age-related decline.”
- Vitamin D: Vitamin D is a fat-soluble vitamin that acts more like a hormone in the body. It’s essential for healthy aging as it regulates calcium and phosphorus absorption, crucial for bone health, and can help balance inflammation too. “Vitamin D maintains bone density, helps avoid infections and supports immune resilience, and reduces frailty especially in older adults,” says Dr. Renna. However, it’s essential to get your levels checked as too much vitamin D could cause toxicity.
- Magnesium Glycinate: Magnesium has been known to help calm stress, improve cognitive function, support digestion, and more. There are different types of magnesium for different benefits. You can typically reach your magnesium goals through a diet rich in leafy greens, nuts, seeds, whole grains, and animal proteins, but supplementing can help if you’re not getting an adequate dose. “Magnesium glycinate is important for metabolism, brain and bone health,” says Dr. Berzin. “Often, today’s food supply is low in magnesium.”
- Curcumin: There are a handful of studies that address the ability of curcumin (the active ingredient in turmeric) to manage and reduce inflammation; it can also help with digestion, as well as help neutralize free radicals.
- Creatine: Creatine is a compound your body makes from amino acids and touts benefits from exercise performance to healthy aging. “Creatine also has strong emerging data behind it for supporting cognitive function and muscular energy, and allowing for more intense exercise,” says Dr. Berzin. “And exercise is one of the strongest predictors of long-term survival.”
- Resveratrol: A natural polyphenol produced by various plants including grapes and blackberries, resveratrol plays an important role in cellular defense systems against oxidative stress. It’s an antioxidant (famously found in red wine) that’s attributed to the “French paradox that has some promising emerging research. “Resveratrol and CoQ10 are often discussed for their roles in oxidative balance and mitochondrial signaling,” says Dr. Berzin. “The biology behind them is real—but translating that biology into meaningful, long-term health benefits from supplementation is far more nuanced than the headlines suggest.”
Are supplements the best way to support healthy aging?
The short answer? No, supplements aren’t the best—or only way—to support healthy aging; but they can help support healthy aging. “Lifestyle habits like exercise, sleep, nutrition, and stress management remain the foundation of healthy aging,” says Dr. Sagner. “Supplements, when chosen carefully, can play a powerful supporting role as they fill nutritional gaps, target specific aging pathways, and help maintain cellular health as we age. The key is to select supplements based on age, individual risk factors, lifestyle, and clinical evidence,” adds Dr. Sagner, used strategically to complement healthy behaviors.
How We Tested
When we test and review a product, we take a holistic approach to deliver well-rounded product recommendations. First, we lean on Vogue’s vast network of experts—from board-certified dermatologists to dietitians—to gain professional acumen on the industry’s standout products, ones these specialists would actually use on their clients. We pair their expertise with our editorial best practices to curate the thoughtful edits you read on our site.
As it relates to anti-aging supplements, we selected the best based on the following characteristics: ingredients, ingredients per serving, form, dosage, and the wellness concerns they address. To do this, we paired our own personal tests of each formula with expert guidance and reviewer insights to determine which we would recommend to you.
Meet the Experts
- Michael Sagner, MD, is a clinical advisor in Longevity and Preventive Medicine at Ageing Research at King’s (ARK), Director of the European Society of Preventive Medicine, founder of The Serena Clinic, and an advisor at Niagen Bioscience.
- Robin Berzin, MD is a physician and founder of Parsley Health.
- Chris Renna, DO is a board-certified family medicine physician and founder of LifeSpan Medicine with clinics in Los Angeles, Miami, and Dallas. He also authored The End of Pain.