Early immune clues that determine who develops TB may lead to new ways to intervene earlier and stop the disease (opens in new tab)

A quarter of the global population is estimated to have been infected with Mycobacterium tuberculosis, yet only 5%–10% of those infected go on to develop active tuberculosis (TB). "The big question has always been what distinguishes people who control the infection from those who don't," says Anne O'Garra, whose lab at the Crick studies how the immune system responds to infection.