Dec. 07, 2025 6:56 PM ET, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
Summary
- Duquesne Family Office’s ~$4.06B 13F portfolio remains concentrated, with the top five holdings—Natera, Insmed, Teva Pharma, Taiwan Semi, and Woodward—comprising ~39%.
- Significant new positions include Amazon, Figure Technology, Stubhub, and Meta Platforms; notable disposals were Microsoft, Eli Lilly, Warner Bros Dis…
Dec. 07, 2025 6:56 PM ET, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
Summary
- Duquesne Family Office’s ~$4.06B 13F portfolio remains concentrated, with the top five holdings—Natera, Insmed, Teva Pharma, Taiwan Semi, and Woodward—comprising ~39%.
- Significant new positions include Amazon, Figure Technology, Stubhub, and Meta Platforms; notable disposals were Microsoft, Eli Lilly, Warner Bros Discovery, and Philip Morris.
- Stake increases in Natera, Insmed, Teva, Coupang, Mercadolibre, and DocuSign, reflecting conviction in these growth-oriented names.
- Several positions, including Woodward, Roku, Citigroup, and EQT, saw reductions, signaling active portfolio rotation and risk management.
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This article is part of a series that provides an ongoing analysis of the changes made to Duquesne Family Office’s 13F stock portfolio on a quarterly basis. It is based on Stanley Druckenmiller’s regulatory 13F
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Quick Insights
NTRA remains the largest position at 13.18% of the portfolio, with a minor ~4% stake increase, reflecting sustained high conviction despite the stock’s significant appreciation.
Both MSFT and LLY were fully exited this quarter after recent purchases, highlighting a willingness to quickly rotate out of large-cap winners and reallocate capital to new opportunities.
New stakes in Amazon (AMZN), Figure Technology (FIGR), Stubhub (STUB), and Meta (META) suggest a renewed focus on technology, digital platforms, and innovation-driven growth.