Physical activity and biological age measured by DNA methylation clocks: a systematic review and meta-analysis (opens in new tab)

chatGPT(5.5paid): Shan et al., “Physical activity and biological age measured by DNA methylation clocks: a systematic review and meta-analysis,” Lancet Healthy Longevity, 2026. This paper asks whether people who are more physically active show a lower “biological age” when measured using DNA methylation clocks. The authors searched six databases from 2011 to June 2025 and included 44 studies covering 145,465 participants. These studies used multiple epigenetic clocks, including first-generati...