A Tale of Two Sexes: Rapamycin and Friends Protect Bone in Females, Lifespan in Males

Three of the best-validated lifespan-extending drugs — rapamycin, acarbose, and 17α-estradiol — all preserved spongy (trabecular) bone in aging female mice but did almost nothing in males. Osteoporosis drugs strengthen bone, but they do nothing about the muscle weakness, poor balance, and failing ey…

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