Correction to: Nature https://doi.org/10.1038/s41586-022-04625-0 Published online 21 March 2022

In the version of the article initially published, the “Animal study and ethics statement” section of the Methods read:

“All animal experiments were performed in accordance with the ethics guidelines of the Guangzhou Institutes of Biomedicine and Health. Human–mouse chimera and human blastoid experiments were approved and followed up by the Animal Care and Use Committee and Human Subject Research Ethics Committee under license numbers IACUC2016012 and GIBH-IRB2020-034, respectively, of the Guangzhou Institutes of Biomedicine and Health. These committees comprise experts in different fields (including scientists working on development and other disciplines, and non-scientists (doctors and lawyers)), and they evaluated the rationale of the experiment plan, origins and consent of human materials and the qualification of the investigators. Several of these experts followed the study until completion. Both experiments followed relevant international regulations, including the 2016 Guidelines for Stem Cell Research and Clinical Translation released by the International Society for Stem Cell Research (ISSCR). A specialized review process was activated in the human–mouse chimera experiments to assess whether the degree of functional integration was sufficiently high to raise concerns that the nature of the chimeric animal would be substantially changed. Human blastoid experiments were subjected to an embryo research oversight process. Several of these experts followed the study until completion. We have consent forms for all iPS cells generated in our laboratory. For the chimera experiments, we used the HN10-DsRed ES cell line, which were established by Hainan Medical University, China. We performed a TPRX1–EGFP knock-in into HN10-DsRed ES cells, as H9 ES cells cannot be used for interspecies chimeras. All human PSC lines were used anonymized”.

It has now been corrected in the HTML and PDF versions of the article to:

“All animal experiments were performed in accordance with the ethics guidelines of the Guangzhou Institutes of Biomedicine and Health. Teratoma experiments were approved by the Institutional Animal Care and Use Committee of the Guangzhou Institutes of Biomedicine and Health under license number IACUC:2021002. Human blastoid experiments were approved by the Institutional Review Board of the Guangzhou Institutes of Biomedicine and Health under license number GIBH-IRB2020-034. Human–mouse chimera experiments were part of work in a team grant of the Chinese Academy of Sciences (XDA16030502). The team in this grant had ethical clearance for work on human-mouse chimeras (license numbers IACUC:2019037 approved by Institutional Animal Care and Use Committee of the Guangzhou Institutes of Biomedicine and Health and GIBH-IRB2019-020 approved by the Institutional Review Board of the Guangzhou Institutes of Biomedicine and Health). The license number for performing embryo-complementation experiments at the facility of the Guangzhou Institutes of Biomedicine and Health was IACUC:2016012 (approved by Institutional Animal Care and Use Committee of the Guangzhou Institutes of Biomedicine). Our research work on human-mouse chimeras was very rigorously overseen on a quarterly basis by a large and independent panel of experts from different disciplines including non-scientific at the Chinese Academy of Sciences. Special care by the reviewing experts was put onto assessing whether the degree of functional integration was sufficiently high to raise concerns that the nature of the chimeric animal would be substantially changed. Several of these experts followed the study until completion. All experiments adhered to the relevant international regulations, including the 2016 Guidelines for Stem Cell Research and Clinical Translation released by the International Society for Stem Cell Research (ISSCR). Human blastoid experiments were subjected to an embryo research oversight process. Several of these experts followed the study until completion. We have consent forms for all iPSCs generated in our laboratory. For the chimera experiments, we used the HN10-DsRed ESC line, which were established by Hainan Medical University, China. We performed a TPRX1–EGFP knock-in into HN10-DsRed ESCs, as H9 and H1 ESCs cannot be used for interspecies chimeras. All human PSC lines were used anonymized”.

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Author notes

These authors contributed equally: Md. Abdul Mazid, Carl Ward, Zhiwei Luo, Chuanyu Liu

Authors and Affiliations

Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

Md. Abdul Mazid, Carl Ward, Zhiwei Luo, Yunpan Li, Yiwei Lai, Wenqi Jia, Hao Liu, Lixin Fu, David P. Ibañez, Junjian Lai, Juan An, Wenjuan Li & Miguel A. Esteban 1.

University of Chinese Academy of Sciences, Beijing, China

Md. Abdul Mazid, Liang Wu, Jinxiu Li, Wenqi Jia, Lixin Fu, David P. Ibañez, Xiaoyu Wei, Yue Yuan & Qiuting Deng 1.

BGI-Shenzhen, Shenzhen, China

Chuanyu Liu, Yiwei Lai, Liang Wu, Jinxiu Li, Xiaoyu Wei, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Xun Xu, Longqi Liu & Miguel A. Esteban 1.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, Key Laboratory of Zoonoses Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China

Yu Jiang, Yueli Yang, Pengcheng Guo & Miguel A. Esteban 1.

School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

Juan An 1.

Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China

Fei Gao 1.

E-GENE, Shenzhen, China

Junwen Wang 1.

Department of Genetic Engineering and Biotechnology, Faculty of Life and Earth Sciences, University of Rajshahi, Rajshahi, Bangladesh

Shahriar Zaman 1.

Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

Baoming Qin 1.

Guangzhou Laboratory, Guangzhou, China

Guangming Wu 1.

Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK

Patrick H. Maxwell 1.

Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, China

Xun Xu 1.

Institute of Stem Cells and Regeneration, Chinese Academy of Sciences, Beijing, China

Miguel A. Esteban

Authors

1. Md. Abdul Mazid
2. Carl Ward
3. Zhiwei Luo
4. Chuanyu Liu
5. Yunpan Li
6. Yiwei Lai
7. Liang Wu
8. Jinxiu Li
9. Wenqi Jia
10. Yu Jiang
11. Hao Liu
12. Lixin Fu
13. Yueli Yang
14. David P. Ibañez
15. Junjian Lai
16. Xiaoyu Wei
17. Juan An
18. Pengcheng Guo
19. Yue Yuan
20. Qiuting Deng
21. Yang Wang
22. Ying Liu
23. Fei Gao
24. Junwen Wang
25. Shahriar Zaman
26. Baoming Qin
27. Guangming Wu
28. Patrick H. Maxwell
29. Xun Xu
30. Longqi Liu
31. Wenjuan Li
32. Miguel A. Esteban

Corresponding authors

Correspondence to Md. Abdul Mazid, Longqi Liu, Wenjuan Li or Miguel A. Esteban.

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Cite this article

Mazid, M.A., Ward, C., Luo, Z. et al. Author Correction: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage. Nature (2025). https://doi.org/10.1038/s41586-025-10044-8

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Published: 23 December 2025

Version of record: 23 December 2025

DOI: https://doi.org/10.1038/s41586-025-10044-8