Running Out of Air: Low Oxygen Fast-Forwards the Aging Clock — But Only in the Old, and the Damage Largely Rewinds

One month of severe intermittent low-oxygen exposure pushed the epigenetic clocks of old mice forward by several “months” of aging across lung, spleen, and heart, while leaving young-adult mice untouched — and most of that acceleration reversed once normal oxygen returned. A parallel human dataset o…

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