Confirming Dehnel’s phenomenon and metabolic profiling of the blood metabolome. Credit: Genome Research (2025). DOI: 10.1101/gr.280639.125

Some mammals hibernate to survive in winter, but the Eurasian common shrew (Sorex araneus) employs Dehnel’s phenomenon to get through it. This is a metabolic process that enables shrews to conserve energy by shrinking their brain and other energy-consuming organs. In the spring, the organs grow back to normal size. Scientists are learning more about how shrews can do this, and their findings may help us understand certain metabolic and neurological diseases.

New studies illuminate shrews’ biology

Two newly published studies by a team of Stony Brook University researchers and their international collaborators uncover genetic and biological changes that occur in the shrew during Dehnel’s phenomenon. One paper, published in Genome Research, breaks down the dynamic metabolic and molecular changes during the shrew’s seasonal shrinking. The second paper, published in Molecular Biology and Evolution, assesses genomic comparisons on the adaptive basis of brain size plasticity and chromosomal instability in the shrew.

"In mammals, Dehnel’s phenomenon is an extreme example of how the same genetic information can result in varying structures. We call that genetic plasticity. Together, these studies show that how the genome is arranged contributes to both the plasticity and evolution or genetic adaptation that enable this tiny shrew to continue being active through the winter, even as it gets colder and food grows scarcer," says Liliana M. Dávalos, Ph.D., Professor in the Department of Ecology and Evolution at Stony Brook University, and the senior author on both papers.

Grey shrew, not a Christmas Island shrew, for which very few photos exist. Credit: Pixabay/CC0 Public Domain

Metabolic shifts during winter months

In the Genome Research paper, the authors show that shrews display regulatory changes in oxidative phosphorylation and increased fatty acid metabolism during autumn into winter, which also occurs in hibernating animals. But the shrews also had an elevated winter expression of genes involved in gluconeogenesis, the biosynthesis of glucose from noncarbohydrate substrates.

The shrews also had an increase in FOXO signaling, part of a cell regulatory metabolic process in homeostasis. And the researchers conclude that with gluconeogenesis, the overexpression of FOXO is central and essential to the brain and organ shrinkage phenomenon.

Genomic architecture behind brain plasticity

Because the genomic contributions to seasonal brain size plasticity in shrews were unknown, the research team also coupled a chromosome-scale genome assembly with seasonal brain transcriptomes to discover relationships between molecular and genetic changes.

They found a few previously unknown gene expression changes that appear to be key mechanisms underlying Dehnel’s phenomenon. They also found that both positively selected and differentially expressed genes in the shrew hippocampus of the brain are overrepresented at open regions of the chromosomes that experience more breaks. This, the authors write, suggests in the shrew "that chromosomal rearrangements are integral to adaptive evolution and the regulation of brain size plasticity."

Broader implications for human health

"Before I had even heard of Dehnel’s phenomenon, I knew these shrews had an unusual number of rearrangements in their chromosomes that evolutionary biologists have studied for decades. Yet I did not expect the rearrangements themselves had something to do with the genes that adapt in this species to generate Dehnel’s phenomenon, to the genes that express more during the cycle of shrinking and regrowing, or to genes that may help repair breaks in the genome," says William R. Thomas, Ph.D., lead author on both papers and a Post-Doctoral Associate in the Department of Ecology and Evolution.

"This shows us how important the structure of the genome is to traits that make shrews unique. Plus, our findings are not confined to shrews," he explains. "The same genes shrews use are also present in humans. How the shrew’s energy management links to brain regrowth can help us figure out how metabolism and brain health can work in people as well."

Publication details

William R. Thomas et al, Dynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus, Genome Research (2025). DOI: 10.1101/gr.280639.125

William R Thomas et al, Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew, Molecular Biology and Evolution (2026). DOI: 10.1093/molbev/msag006

Citation: The unraveling of the shrew, in winter: Studies decode genetic basis of seasonal organ shrinkage in mammals (2026, February 3) retrieved 3 February 2026 from https://phys.org/news/2026-02-unraveling-shrew-winter-decode-genetic.html

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