PLOS Biology journals.plos.org

The details and entropy demons in a transmembrane allosteric machine

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Enrichment of root-associated <i>Streptomyces</i> strains in response to drought is driven by diverse functional traits and does not predict beneficial effects ...

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Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity

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The host range of generalist and specialist phages in capsule-diverse <i>Klebsiella</i> hosts is driven by the evolvability of receptor-binding proteins

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A novel targeting domain directs essential components of the cytosolic iron–sulfur cluster assembly pathway to the mitochondrion of <i>Toxoplasma</i> parasites

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Context-dependent activation of V1 parvalbumin interneurons enhances visual discrimination

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Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial ...

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The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in <i>Streptomyces</i>

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Episodic memory involves transient and sparse connectivity aligned to both internal and external events

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Collaborative rule learning promotes interbrain information alignment

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RNG2 tethers the conoid to the apical polar ring in <i>Toxoplasma gondii</i> to enable parasite motility and invasion

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STUPPIT is a proximity labeling tool for labeling intermediary proteins that bridge two non-interacting proteins

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The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

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Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents

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Efficient and reliable spike sorting from neural recordings with UMAP-based unsupervised nonlinear dimensionality reduction

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The efficacy of longevity interventions in <i>Caenorhabditis elegans</i> is determined by the early life activity of RNA splicing factors

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Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems

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Nanobody-drug conjugates for targeting specific GPCR pairs

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Benchmarking with synthetic communities provides a baseline for virus-host inferences from Hi-C proximity linking

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Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling

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