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The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

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Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents

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Efficient and reliable spike sorting from neural recordings with UMAP-based unsupervised nonlinear dimensionality reduction

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The efficacy of longevity interventions in <i>Caenorhabditis elegans</i> is determined by the early life activity of RNA splicing factors

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Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems

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Nanobody-drug conjugates for targeting specific GPCR pairs

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Benchmarking with synthetic communities provides a baseline for virus-host inferences from Hi-C proximity linking

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Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling

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Sleep deprivation and sleep intensity exert distinct effects on cerebral vasomotion and brain pulsations driven by the respiratory and cardiac cycles

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Editorial Note: Global Regulator SATB1 Recruits β-Catenin and Regulates T<sub>H</sub>2 Differentiation in Wnt-Dependent Manner

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Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation

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Diverse biophysical and molecular mechanisms drive phytoplankton sinking in response to starvation

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Bacterial immune systems as causes and consequences of microbiome structure

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Transient frontopolar cortex stimulation induces prolonged disruption to counterfactual processing

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Eye blinks synchronize with musical beats during music listening

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The blood–brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in <i>Drosophila</i>

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Cell2Spatial is a computational framework that maps single cells to spatial transcriptomic spots to reconstruct tissue architecture

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Chromosome duplication causes premature aging via defects in ribosome quality control

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The body sends a signal: Perspectives on interoception

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A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day

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