Molecular Systems Biology · Scour

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Differential nucleosome organization in human interphase and metaphase chromosomes

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Genetic barcoding uncovers the clonal makeup of solid and liquid biopsies and their ability to capture intra-tumoral heterogeneity

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Proteome-wide AlphaFold pool party

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Essentiality and dynamic expression of the human tRNA pool during viral infection

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Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson’s disease

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Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies

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Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3

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Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets

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A universal surface functionalization technique to chemically enhance live microbial cells

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Integrative multi-omics defines melanoma drug response networks and ARID1A-dependent resistance mechanisms

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A novel combination therapy for ER+ breast cancer suppresses drug resistance via an evolutionary double-bind

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The evolutionary dynamics between viral mimics and host proteins

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Spatially-guided metabolomics profiling of metabolic regions in human tumor tissues

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Scientific obituary: Peer Bork

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Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME

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VEFill: accurate and generalizable deep mutational scanning score imputation across protein domains

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Progress and new challenges in image-based profiling

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