Genomics-Informed Approach Identifies Which Cell Types Regulate the Metabolome (opens in new tab)

AbstractMetabolism occurs in a cell type-specific manner, but which cells regulate metabolite levels remains unclear. Here, we integrate some of the largest metabolite quantitative trait loci datasets, TOPMed and UK Biobank, with one of the most extensive single-cell RNA sequencing resources, Tabula Sapiens. This integration allows us to identify cell types that regulate metabolites body-wide. We find hepatocytes are the primary regulatory cell type for most metabolites, associating with 385/...