Harmonization and Integration of Pharmacogenomics Screens (opens in new tab)

AbstractMotivationLarge pharmacogenomics screens have generated a wealth of information cataloguing the responses of more than a thousand tumor cell-line models to FDA-approved and exploratory drugs. Although centralized repositories have consolidated data access, the diversity of experimental platforms and response metrics used in these screens have made it challenging to integrate and compare their measured drug responses. Towards better pharmacogenomic data harmonization, we surveyed a ran...