barbieQ: an R software package for analysing barcode count data from clonal tracking experiments (opens in new tab)

AbstractMotivationA ‘clone’ encompasses a progenitor cell and its progeny cells. Tracking clonal composition as cells differentiate or evolve is useful in many fields. Various single-cell lineage tracing (clonal tracking) technologies use unique DNA barcodes that are passed from progenitor cells to their offspring. The barcode count for each sample indicates cell number in clones. However, analysis of barcode count data is often bespoke and relies on visualisations and heuristics. A generaliz...