ChromBERT-tools: A versatile toolkit for context-specific regulatory representations of transcription regulators across different cell types (opens in new tab)

AbstractSummaryRepresentations that encode the genome-wide regulatory behavior of transcription regulators provide a foundation for flexible transcription modeling and in silico regulatory analysis. Existing regulator representations are commonly derived from gene co-expression, motif annotations, or static protein features, which capture useful but limited aspects of regulator identity but do not directly model how regulators participate in region-specific regulatory programs across the geno...