DirectASRM: Uncovering allele-specific post-transcriptional RNA modifications through direct RNA sequencing (opens in new tab)

AbstractSummaryWe developed DirectASRM, a comprehensive database for the systematic identification, integration, and annotation of allele-specific RNA modifications (ASRMs) from direct RNA sequencing data. DirectASRM enables single-base, transcript-level detection of ASRMs across multiple RNA modification types, diverse organisms and condition-specific contexts. The database further evaluates the confidence of each ASRM–SNP pair association within isoform context by jointly considering statis...