SegJointGene: joint cell segmentation and spatial gene prioritization by information entropy guided convolutional neural networks (opens in new tab)

AbstractMotivationSpatial sequencing technologies enable the single-cell-level study of molecular organization in tissues. Revealing such spatial patterns relies on accurate cell segmentation. In complex tissues with dense cell packing, segmentation based solely on nuclear staining is insufficient for accurate cell boundary detection. This limitation arises because accurate segmentation necessitates the delineation of cell morphology, which is driven by molecular activities such as cytoskelet...