Local imperfect feedback control in non-equilibrium biophysical systems enabled by thermodynamic constraints (opens in new tab)

How biological networks achieve robust control despite relying on imperfect, local information remains an important open question. Here, we identify thermodynamic constraints that can curtail non-equilibrium steady-state responses so severely that even crude, local feedback rules can achieve globally stable control without requiring precise network design or global information. Specifically, using Markov jump processes as a general framework...