Phase Behavior of Unilamellar Hybrid Lipid-Diblock Copolymer Membranes (opens in new tab)

Hybrid lipid block copolymer membranes are promising for many applications in drug delivery, single molecule detection, in-membrane protein folding, and synthetic cells. However, rational design is difficult due to the many design parameters which determine the nano- and micron-scale morphology and properties. In this work, we propose a physically-informed framework which incorporates chemical immiscibility, hydrophobic thickness mismatch and ge...