Anchors Away: Navigating Unanchored Indirect Comparisons with Multilevel Unanchored Meta-Regression (ML-UMR) (opens in new tab)

Unanchored indirect treatment comparisons using single-arm studies or disconnected evidence are increasingly used in health technology assessment (HTA) when randomized evidence is unavailable. Existing methods, including matching-adjusted indirect comparison (MAIC) and simulated treatment comparison (STC), are generally limited to pairwise settings and typically estimate marginal effects in the comparator study population, which may differ from ...