Mechanistic mathematical model of the in vitro infection dynamics of Bunyamwera and Batai viruses including MOI-dependent shortening of the eclipse phase (opens in new tab)

We develop a deterministic mathematical model to quantify the distinct in vitro infection dynamics of Bunyamwera virus (BUNV) and Batai virus (BATV) in A549 cells, incorporating cell division and natural death, continued entry of virions into already-infected cells, and shortening of the eclipse phase driven by re-infection. The model parameters were estimated making use of viral decay data, growth curves at two different inoculum concentrations...