Residue-Level Attributions in Protein Language Models Do Not Recover Allergen Epitopes (opens in new tab)

Deep allergenicity classifiers are increasingly used in safety screening of novel foods, and recent protein language models have substantially improved protein-level allergenicity prediction. However, whether their explanations capture biologically meaningful information remains unclear. We introduce an epitope-grounded residue-level benchmark for quantitatively evaluating attribution faithfulness in protein allergenicity models. Across frozen E...