PROMPT: A Pre-registered Randomized Protocol for Component-Level Evaluation of Clinical AI Prompts (opens in new tab)

BACKGROUND:Prompt engineering shapes medical AI outcomes, but prompt components are rarely tested as clinical interventions. We developed PROMPT (Pre-registered Randomized Outcome Measurement for Prompt Testing), a protocol using pre-specification, randomization, matched controls, dismantling, and decision rules.METHODS:Two pre-registered demonstrations used Claude Sonnet 4.6. Exp 1 used a synthetic tumbling-E orientation task: 630-trial main st...