Kinetics of multistate DNA polymerases (opens in new tab)

In the present paper, we apply the iterative mathematical method previously developed for the kinetics of template-directed multistate copolymerization to the kinetics of DNA replication by polymerases having multiple structural states. In particular, we study a two-state kinetic model for the T7 DNA polymerase. We obtain the mean velocity for the growth of the copy along the template, the error probability of DNA replication by the polymerase, ...