Topological Polar Surface Area Cheat Sheet (opens in new tab)

TPSA (topological polar surface area) is one of the most commonly used molecular descriptors in medicinal chemistry for predicting properties such as membrane permeability, transporter-mediated efflux, oral absorption, and CNS penetration. In this TPSA cheat sheet, we summarize the contributions of common functional groups and heterocycles to help medicinal chemists quickly assess how structural modifications influence polar surface area.