Layer-specific wide-field calcium imaging of neocortical activity (opens in new tab)

The mammalian neocortex comprises multiple regions, each containing a local microcircuitry that is a variation of the canonical six-layer architecture (Szentágothai, 1978; Douglas and Martin, 2004). Long-range projections between the neocortical regions form a densely connected large-scale neural network (Gămănuţ et al., 2018), which enables perception, cognition, and adaptive behavior. A large diversity of neurons populates the cortical layers (Ranson and Clark, 1959; Yao et al., 2023; Zhang...