Cell-autonomous control coupled with tissue context regulates the cessation of migration at the site of organ development (opens in new tab)

ABSTRACTOrgan development relies on interactions among different cell types that form three-dimensional structures to carry out specific tasks. This process often involves active migration of progenitor cells toward specific positions within the embryo, where the cells then become immotile and form stable connections among themselves and with neighboring cells. In this work, we study the process of motility loss using zebrafish primordial germ cells (PGC) as an in vivo model. We show that cha...