Laminin α5 and integrins α3 and α6 coordinately regulate collective cell migration in vivo (opens in new tab)

ABSTRACTCollective cell migration is essential for development and tissue homeostasis, yet how integrin-extracellular matrix adhesion coordinates migratory force generation in vivo remains poorly understood. Here, we have used the zebrafish posterior lateral line primordium (pLLP) as a model for epithelial collective cell migration. We show that integrins α3 and α6b are expressed in different, yet overlapping, domains of the pLLP and function redundantly to support migration. The systematic c...