The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a during postnatal development (opens in new tab)

ABSTRACTThe enthesis is a specialized tissue crucial for transmission of muscle force from tendon to bone, yet its postnatal development is not fully understood. In this study, we investigated if and how hypoxia inducible factor 1 alpha (HIF-1α) regulates enthesis cell adaptation, e.g. cell survival and extracellular matrix (ECM) deposition. We investigated the spatial and temporal dynamics of hypoxia in the murine Achilles tendon enthesis and found that, whereas neonatal tendons rapidly reso...