Plasmin and sterile inflammation jointly drive fatal embryonic liver degeneration in endothelial chromatin remodeler mutant mice (opens in new tab)

ABSTRACTEmbryonic livers undergo extensive vascular expansion after midgestation to support rapid growth and evolving functions. Immature embryonic vessels receive structural support from extracellular matrix (ECM), which is also essential for normal liver development and function. Meanwhile, pro-inflammatory cytokines that promote hematopoiesis and hepatic organogenesis must be tightly regulated to prevent sterile inflammation. However, endothelial contributions to ECM and cytokine productio...