Adhesion and polarity-driven morphogenesis: Mechanisms and constraints in tissue formation (opens in new tab)

Author summary Living organisms build their bodies through morphogenesis, during which cells autonomously arrange themselves into functional structures such as sheets, tubes, and spheres. From simple monolayered spheres to complex multilayered tissues organized by adhesion, it remains unclear how such diverse forms arise. Here, we mathematically modeled a population of proliferating cells governed only by two microscopic factors: the polarity strength of the cell and the time scale at which p...