scMagnifier: Resolving fine-grained cell subtypes via GRN-informed perturbations and consensus clustering (opens in new tab)

Author summary Understanding the diversity of cells in tissues is key to studying health and disease, but identifying subtle differences between closely related cell types is often challenging. Small molecular variations and technical noise can hide rare immune cells, transitional states, or tumor subtypes. We developed scMagnifier, a computational tool that amplifies these subtle differences by simulating genetic perturbations, allowing cells to be grouped into fine-grained subtypes more acc...