Assessing the importance of sex and disease-specific anatomy in electrophysiology and mechanical simulations with a newly developed public virtual cohort of four-chamber heart models (opens in new tab)

Author summary Understanding how sex and disease affect the heart’s electrical and mechanical behaviour is essential for developing accurate and credible computational models. In this study, we built a balanced virtual cohort of fifty patient-specific, four-chamber heart models from male and female individuals with and without heart failure. We designed a single, streamlined pipeline to generate these models and ran benchmark simulations of electrical activation and passive inflation to evalu...