Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding (opens in new tab)

Author summary Huntington’s Disease is a severe brain disorder caused by a mutation that makes a part of the huntingtin gene much longer than normal. This change affects how the gene’s RNA interacts with proteins that normally control how long RNAs live and how much protein they produce. One of these proteins, called MID1, attaches more strongly to the mutant huntingtin RNA and increases the amount of mutant huntingtin protein, which may worsen the disease. In this study, we use mathematical ...