Cell differentiation can underpin the reproducibility of morphogenesis (opens in new tab)

Author summary An astounding property of multicellular animals is the reliable formation of morphological structures, such as organs and limbs. How does this reliable formation, termed reproducibility, arise despite the inherent noise of biological systems? To understand the origins of reproducibility, we developed a computational model of multicellular morphologies. We applied an evolutionary algorithm to our model to search for different kinds of complex morphologies. We found that a signif...