Deciphering cell type-specific causal genetic effects on brain imaging-derived phenotypes and disorders with single-cell Mendelian randomization (opens in new tab)

Author summary Our understanding of how genes influence brain phenotypes at the cell type level remains limited. Although genome-wide association studies (GWASs) have identified numerous genetic variants associated with brain structure and disease, the majority reside in non-coding regions and do not directly implicate specific genes or cell types. Here, we integrate GWAS summary statistics with cis-expression quantitative trait loci (cis-eQTL) data from eight brain cell types to identify gen...