Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury (opens in new tab)

Author summary Senescence is a key manifestation of aging at the cellular level, caused by damage incurred by cells in time. In spite of their wide-ranging implications on how our multicellular bodies age, senescent cells are very challenging to identify due to their complex nature: many different aspects of cells are affected by this cellular state. This complicates defining clear criteria that help us decide whether a cell is senescent or not. In this paper, we propose a computational pipel...