A novel biclustering algorithm for mining m 6 A co-methylation patterns based on beta-binomial distribution and data screening strategy (opens in new tab)

Author summary Methylation of RNA molecules—specifically a modification known as m⁶A—plays a crucial role in how our cells function, influencing everything from normal development to diseases like cancer. However, studying these modifications is challenging because the sequencing technology used to detect them produces noisy data, making it difficult to distinguish genuine biological signals from technical errors. We developed a new computational approach called EBBM that tackles this problem...