Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME (opens in new tab)

Tumor microenvironment (TME) is characterized by a milieu of distinct cell types that exist in heterogenous transcriptional states across tumors. Functional interactions among these cell states drive tumor progression and therapy response. Systematic characterization of functional cell-state interactions (CSIs) remains challenging due to the paucity of scRNA-seq cohorts with clinical information on one hand, and the lack of cellular context in bulk RNA-seq cohorts on the other. We present CSI...