Spatially-guided metabolomics profiling of metabolic regions in human tumor tissues (opens in new tab)

Bulk high-resolution mass spectrometry provides sensitive and global snapshots of metabolites involved in cancer metabolism. However, intratumoral heterogeneity obscures the cellular origins of detected metabolites, making it difficult to identify reproducible and predictive metabolic markers. Here, we present “Spatially guided MEtabolomics (SgME) profiling”, a multi-modal metabolomics data analysis approach that delineates and maps metabolic regions (MERs), including overlapping regions, wit...