Active learning-guided mechanistic modeling reveals context-specific regulators of CXCL9 expression in pancreatic cancer cells (opens in new tab)

Cold tumors like pancreatic cancer suffer from poor immune infiltration, limiting effective anti-tumor responses. The chemokine CXCL9 promotes immune cell recruitment, but the signaling mechanisms regulating its expression in tumor cells remain poorly understood and underexplored as targets for modulation. We present a framework that integrates active learning with mechanistic logic-ODE models to guide perturbation screenings and uncover regulators of CXCL9 in pancreatic cancer cells. Using p...