Interpretable multi-omics integration across mixed-order tensors with MANTRA (opens in new tab)

The integration of multi-modal molecular data is crucial for understanding complex diseases, but existing methods struggle with modern experimental designs that generate datasets with mixed-order tensors—for example, a third-order drug–response tensor alongside a second-order transcriptomics matrix. Here, we present MANTRA (Multi-view ANalysis with Tensor and matRix Alignment), a probabilistic framework that integrates collections of tensors of different orders, combining the strengths of gro...