Signed motif analysis of the Caenorhabditis elegans neuronal network reveals positive feedforward and negative feedback loops (opens in new tab)

Nervous systems are complex biological networks with largely unknown structural and functional characteristics. Motif analysis is a robust tool that can reveal the unique aspects of connectivity in a complex network. An ideal candidate for motif analysis is the connectome of the nematode Caenorhabditis elegans, which is the first fully reconstructed nervous system. We performed, for the first time, edge polarity-based signed motif analysis on the C. elegans connectome using recent data on the...