Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines (opens in new tab)

Intermembrane lipid transfer protein VPS13A (VPS13A) is a large protein whose cellular functions are still under investigation. VPS13A gene mutations leading to the absence of protein expression cause Chorea-acanthocytosis (ChAc), an ultra-rare inherited neurodegenerative movement disorder. Although the molecular mechanisms linking VPS13A loss to neuronal dysfunction remain unclear, its role as a bulk lipid transfer protein suggests that impaired lipid distribution may represent a primary pat...